Fgr may phosphorylate p38 MAPK Authored: Akkerman, JW, 2009-09-04 EC Number: 2.7.10.2 Edited: Jupe, S, 2010-06-07 LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved. Pubmed10754332 Pubmed17339487 Reactome Database ID Release 43432148 Reactome, http://www.reactome.org ReactomeREACT_23951 Reviewed: Kunapuli, SP, 2010-06-07 has a Stoichiometric coefficient of 2