(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA] guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1] AMP + H2O => IMP + NH3 [AMPD] dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK] deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK] (2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK] Adenine + PRPP => AMP + PPi hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP] guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP] N6-methyl-AMP + H2O => IMP + methylamine GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2] PathwayStep2223 PathwayStep2224 PathwayStep2225 PathwayStep2226 PathwayStep2227 PathwayStep2218 PathwayStep2219 PathwayStep2217 PathwayStep2222 PathwayStep2221 PathwayStep2220 Purine salvage Authored: Jassal, B, 2003-07-17 08:31:43 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0043101 Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by DNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathways of purine biosynthesis. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974). Pubmed4620886 Reactome Database ID Release 4374217 Reactome, http://www.reactome.org ReactomeREACT_1923