Adenylosuccinate => AMP + Fumarate IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] AIR + CO2 => CAIR FGAM + ATP => AIR + ADP + Pi SAICAR => AICAR + Fumarate CAIR + Aspartate + ATP => SAICAR + ADP + Pi FAICAR => IMP + H2O AICAR + 10-Formyl-THF => FAICAR + THF XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi GAR + 10-Formyl-THF => FGAR + THF 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer Formation of phosphoribosyl pyrophosphate amidotransferase tetramer PathwayStep2200 PathwayStep2214 PathwayStep2215 PathwayStep2212 PathwayStep2213 PathwayStep2209 PathwayStep2205 PathwayStep2206 PathwayStep2207 PathwayStep2208 PathwayStep2201 PathwayStep2202 PathwayStep2203 PathwayStep2204 PathwayStep2211 PathwayStep2210 Purine ribonucleoside monophosphate biosynthesis Authored: Jassal, B, 2003-06-26 04:06:16 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0009168 Pubmed1574589 Reactome Database ID Release 4373817 Reactome, http://www.reactome.org ReactomeREACT_1776 The purine ribonucleotide inosine 5'-monophosphate (IMP) is assembled on 5-phospho-alpha-D-ribose 1-diphosphate (PRPP), with atoms derived from aspartate, glutamine, glycine, N10-formyl-tetrahydrofolate, and carbon dioxide. Although several of the individual reactions in this sequence are reversible, as indicated by the double-headed arrows in the diagram, other irreversible steps drive the pathway in the direction of IMP synthesis in the normal cell. All of these reactions are thus annotated here only in the direction of IMP synthesis. Guanosine 5'-monophosphate (GMP) and adenosine 5'-monophosphate (AMP) are synthesized from IMP.