2 H2O2 => O2 + 2 H2O 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O Xanthine + H2O + O2 => Urate + H2O2 AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E] (deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP] (deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP] Guanine + H2O => Xanthine + NH3 Hypoxanthine + H2O + O2 => Xanthine + H2O2 (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2] AMP + H2O => adenosine + orthophosphate [NT5C1B] (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C] PathwayStep2236 PathwayStep2237 PathwayStep2234 PathwayStep2235 PathwayStep2238 PathwayStep2239 PathwayStep2240 PathwayStep2229 PathwayStep2231 PathwayStep2230 PathwayStep2233 PathwayStep2232 Purine catabolism Authored: Jassal, B, 2003-07-17 08:31:43 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0006195 Pubmed4620886 Reactome Database ID Release 4374259 Reactome, http://www.reactome.org ReactomeREACT_2086 The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.