Na+/Ca2+ exchanger transport Authored: Jassal, B, 2009-06-05 Edited: Jassal, B, 2009-06-05 Pubmed12406570 Pubmed1374913 Pubmed8021246 Reactome Database ID Release 43425661 Reactome, http://www.reactome.org ReactomeREACT_19164 Reviewed: He, L, 2009-08-24 The NCX (SCL8, Na+/Ca2+ exchanger) family is one of three families that control Ca2+ flux across the plasma membrane or intracellular compartments. They extrude Ca2+ from the cell, using the electrochemical gradient of Na+ as it flows into the cell. One Ca2+ is exchanged for three Na+. During this electrogenic exchange, the membrane potential is altered. NCX1 (SLC8A1) has a ubiquitous expression profile (highest expression in heart, brain and kidney) and was originally cloned and characterized from human cardiac muscle (Komuro I et al, 1992). Both NCX2 (SLC8A2) (Li Z et al, 1994) and NCX3 (SLC8A3) (Gabellini N et al, 2002) are expressed in the brain. has a Stoichiometric coefficient of 3