GPVI:FceRI gamma:FYN:LYN:Collagen I GPVI:FceRI gamma:FYN:LYN Collagen I Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Edited: Jupe, S, 2009-11-02 GPVI receptor has little affinity for soluble forms of collagen but binds collagen fibrils. Recent structural models indicate that each GPVI receptor complex could bind up to 3 collagen fibrils (Jung & Moroi 2008). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FceRIgamma complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FceRIgamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. Pubmed19065783 Pubmed9295288 Reactome Database ID Release 43114577 Reactome, http://www.reactome.org ReactomeREACT_1088 Reviewed: Harper, MT, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 Reviewed: Poole, AW, 2009-11-02