Integrin alpha2beta1 Integrin alpha2beta1:Collagen I:Mg++ Procollagen type I Integrin alpha2beta1 collagen adhesion Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Integrin Alpha2 Beta1, known on leukocytes as VLA-2, is the major platelet collagen receptor (Kunicki et al. 1988). It requires Mg2+ to interact with collagen and may require initiation mediated by the activation of AlphaIIbBeta3 (van de Walle 2007). Binding occurs via the alpha2 subunit I domain to a collagen motif with the sequence Gly-Phe-Hyp-Gly-Glu-Arg (Emsley 2000). Binding of collagen to Alpha2 Beta1 generates the intracellular signals that contribute to platelet activation. Pubmed10778855 Pubmed16985184 Pubmed2832397 Reactome Database ID Release 43114563 Reactome, http://www.reactome.org ReactomeREACT_1990 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37