eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 eNOS:Caveolin-1 complex binds to Nostrin NOSTRIN mediated translocation of eNOS from plasma membrane eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP PathwayStep2127 PathwayStep2126 PathwayStep2125 PathwayStep2124 NOSTRIN mediated eNOS trafficking GENE ONTOLOGYGO:0050999 Pubmed12446846 Pubmed12842859 Pubmed16234328 Pubmed16722822 Reactome Database ID Release 43203641 Reactome, http://www.reactome.org ReactomeREACT_12541 Reviewed: Enikolopov, G, 2008-02-28 17:52:44 eNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellular vesicular structures. NOSTRIN functions as an adaptor protein through homotrimerization and recruitment of eNOS, dynamin-2, and N-WASP to its SH3 domain. Studies indicated that NOSTRIN may facilitate vesicle fission and endocytosis of eNOS by coordinating the function of dynamin and N-WASP, which in turn, recruits the Arp2/3 complex, initiating actin filament polymerization. Overall, this process is thought to occur via caveolar endocytosis. <br><br><br><br>