eNOS binds NOSIP eNOS:NOSIP translocation from caveolae to intracellular compartments PathwayStep2121 PathwayStep2122 NOSIP mediated eNOS trafficking GENE ONTOLOGYGO:0050999 Pubmed11149895 Pubmed12842859 Pubmed16135813 Pubmed16234328 Pubmed16722822 Reactome Database ID Release 43203754 Reactome, http://www.reactome.org ReactomeREACT_12510 Reviewed: Enikolopov, G, 2008-02-28 17:52:44 eNOS-interacting protein (NOSIP) is a 34-kDa nucleocytoplasmic shuttling protein that binds to the COOH-terminal region (amino acids 366-486) of the eNOS oxygenase domain. This protein association promotes translocation of eNOS from the plasma membrane caveolae to the cytoskeleton and inhibits eNOS activity. Studies have found that NOSIP accumulates in the cytoplasm specifically during the G2 phase of the cell cycle.