cGMP is degraded by PDEs Authored: Akkerman, JW, 2009-06-03 Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11).  The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.<br>PDE2, 3 and 5 are expressed in platelets. EC Number: 3.1.4.35 Edited: Jupe, S, 2010-06-07 Pubmed17307970 Pubmed8557689 Reactome Database ID Release 43418456 Reactome, http://www.reactome.org ReactomeREACT_23959 Reviewed: Kunapuli, SP, 2010-06-07