PathwayStep1013 PathwayStep1009 PathwayStep1011 Insulin effects increased synthesis of Xylulose-5-Phosphate Authored: Gopinathrao, G, 2005-05-13 15:44:47 GENE ONTOLOGYGO:0005999 ISBN0781721458 One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A. Pubmed12110366 Pubmed3539386 Reactome Database ID Release 43163754 Reactome, http://www.reactome.org ReactomeREACT_939 D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate