Nuclear transport of pChREBP (Thr 666) protein Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA PhosphoChREBP (Thr 666) is exported to cytosol Phosphorylation of ChREBP at Thr(666) by PKA PathwayStep2082 PathwayStep2085 PathwayStep2083 PathwayStep2084 PathwayStep968 PKA-mediated phosphorylation of key metabolic factors Authored: Gopinathrao, G, 2005-05-12 21:32:40 GENE ONTOLOGYGO:0007243 Pubmed12626323 Pubmed12721358 Reactome Database ID Release 43163358 Reactome, http://www.reactome.org ReactomeREACT_1525 Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions. Phosphorylation of PF2K-Pase by PKA catalytic subunit