PathwayStep2095 PathwayStep2094 Dephosphorylation of pChREBP (Ser 196) by PP2A Dephosphorylation of pChREBP (Thr 666) by PP2A Dephosphorylation of pChREBP (Ser 568) by PP2A PathwayStep2093 PathwayStep940 PP2A-mediated dephosphorylation of key metabolic factors A member of the PP2A family of phosphatases dephosphorylates both cytosolic and nuclear forms of ChREBP (Carbohydrate Response Elemant Binding Protein). In the nucleus, dephosphorylated ChREBP complexes with MLX protein and binds to ChRE sequence elements in chromosomal DNA, activating transcription of genes involved in glycolysis and lipogenesis. The phosphatase is activated by Xylulose-5-phosphate, an intermediate of the pentose phosphate pathway (Kabashima et al. 2003). The rat enzyme has been purified to homogeneity and shown by partial amino acid sequence analysis to differ from previously described PP2A phosphatases (Nishimura and Uyeda 1995) - the human enzyme has not been characterized. Authored: Gopinathrao, G, 2005-05-12 21:32:40 Pubmed12684532 Pubmed12721358 Pubmed7592845 Reactome Database ID Release 43163767 Reactome, http://www.reactome.org ReactomeREACT_705 Dephosphorylation of phosphoPFKFB1 by PP2A complex