Phosphorylation of ChREBP at Serine 568 by AMPK PathwayStep2091 PathwayStep2090 AMP binds to gamma subunit of AMP kinase heterotrimer LKB1 phosphorylates the alpha subunit of AMPK heterotrimer PathwayStep2089 AMPK inhibits chREBP transcriptional activation activity AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways. Authored: Gopinathrao, G, 2005-05-12 21:32:40 GENE ONTOLOGYGO:0042304 Pubmed10698692 Pubmed11724780 Pubmed12829246 Pubmed15509864 Reactome Database ID Release 43163680 Reactome, http://www.reactome.org ReactomeREACT_1988