cAMP induces dissociation of inactive PKA tetramers Activated Adenylate cyclase catalyses cAMP synthesis PathwayStep2078 PathwayStep2079 PKA activation in glucagon signalling Adenylate cyclase catalyses the synthesis of cyclic AMP (cAMP) from ATP. In the absence of cAMP, protein kinase A (PKA) exists as inactive tetramers of two catalytic subunits and two regulatory subunits. cAMP binding to PKA tetramers causes them to dissociate and release their catalytic subunits as active monomers. Four isoforms of the regulatory subunit are known, that differ in their tissue specificity and functional characteristics, but the specific isoform activated in response to glucagon signaling has not yet been identified. Authored: Gopinathrao, G, D'Eustachio, P, 2005-05-19 14:01:31 Reactome Database ID Release 43164378 Reactome, http://www.reactome.org ReactomeREACT_1946