Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex Activation of Phospholipase C Beta by Gq alpha Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1 Binding of fatty acid ligands by Free fatty acid receptor 1 (GPR40) Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex PathwayStep2036 PathwayStep2037 PathwayStep2032 PathwayStep2031 PathwayStep2030 Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1) Authored: May, B, 2009-08-28 Edited: May, B, 2009-08-28 Fatty acids augment the glucose triggered secretion of insulin through two mechanisms: intracellular metabolism and activation of FFAR1 (GPR40), a G-protein coupled receptor. Based on studies with inhibitors of G proteins such as pertussis toxin FFAR1 is believed to signal through Gq/11. Binding of free fatty acids by FFAR1 activates the heterotrimeric Gq complex which then activates Phospholipase C, producing inositol 1,4,5-trisphosphate and eventually causing the release of intracellular calcium into the cytosol. From experiments in knockout mice it is estimated that signaling through FFAR1 is responsible for about 50% of the augmentation of insulin secretion produced by free fatty acids. Reactome Database ID Release 43434316 Reactome, http://www.reactome.org ReactomeREACT_19193 Reviewed: Kebede, M, 2009-09-09 Reviewed: Madiraju, MS, 2009-10-02 Reviewed: Poitout, V, 2009-09-09