PathwayStep1937 PathwayStep1938 PathwayStep1939 PathwayStep1940 Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 15S-HETE is oxidised to 15-oxoETE by 15-HEDH 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B Synthesis of 15-eicosatetraenoic acid derivatives Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 GENE ONTOLOGYGO:0019372 ISBN978-0-444-53219-0 Pubmed19244215 Reactome Database ID Release 432142770 Reactome, http://www.reactome.org ReactomeREACT_150422 Reviewed: Rush, MG, 2012-11-10 The 15-eicosatetraenoic acids: 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxo-eicosatetraenoic acid (15-oxoETE) are formed after the initial step of arachidonic acid oxidation by the arachidonate 15-lipoxygenases (ALOX15 and ALOX15B) (Buczynski et al. 2009, Vance & Vance 2008).