PathwayStep1945 PathwayStep1946 PathwayStep1942 PathwayStep1943 PathwayStep1944 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 Arachidonic acid is oxidised to 12R-HpETE by ALOX12B Arachidonic acid is converted to 12-oxoETE by ALOX12 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 Synthesis of 12-eicosatetraenoic acid derivatives Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 GENE ONTOLOGYGO:0019372 ISBN978-0-444-53219-0 Pubmed19244215 Reactome Database ID Release 432142712 Reactome, http://www.reactome.org ReactomeREACT_150201 Reviewed: Rush, MG, 2012-11-10 The 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoic acid (12-HpETE), 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-oxo-eicosatetraenoic acid (12-oxoETE) are formed after the initial step of arachidonic acid oxidation by the arachidonate 12 and 15 lipoxygenases (ALOX12, ALOX12B and ALOX15 respectively). This part of the pathway is bifurcated at the level of 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE), which can either be reduced to 12S-hydro-eicosatetraenoic acid (12S-HETE) or converted to hepoxilins (Buczynski et al. 2009, Vance & Vance 2008).