PathwayStep1871 PathwayStep1872 PathwayStep1873 PathwayStep1874 PathwayStep1875 PathwayStep1876 PathwayStep1870 PathwayStep1869 PathwayStep1868 PathwayStep1867 Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA Translocation of tetracosapentaenoyl-CoA to peroxisomes Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA Translocation of DPA to the ER Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA Elongation of arachidonyl-CoA to docosatetraenoyl-CoA Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA Activation of linoleic acid to linoleoyl-CoA Linoleic acid (LA) metabolism Authored: Garapati, P V, 2012-01-11 Edited: Garapati, P V, 2012-01-11 GENE ONTOLOGYGO:0043651 Linoleic acid (LA, 18:2(n-6)) is an omega-6 fatty acid obtained through diet, mainly from vegetable oils. Omega-6 fatty acids helps stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The linoleic acid pathway involves the following steps: 18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6). Two desaturation enzymes are involved in this process: delta-6 desaturase which converts 18:2(n-6) to 18:3 (n-6) and 24:4(n-6) to 24:5(n-6) respectively, and delta-5 desaturase which converts 20:3(n-6) to 20:4(n-6). (Sprecher 2002). Pubmed10903473 Pubmed12324224 Pubmed14636670 Pubmed17168669 Pubmed8609415 Reactome Database ID Release 432046105 Reactome, http://www.reactome.org ReactomeREACT_121100