PathwayStep1841 PathwayStep1840 PathwayStep1845 PathwayStep1844 PathwayStep1843 PathwayStep1842 PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane Synthesis of PIPs at the late endosome membrane At the late endosome membrane, the primary event is the dephosphorylation of the phosphoinositide phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006661 Pubmed10805725 Pubmed11733541 Pubmed17556371 Pubmed17651088 Pubmed18524850 Pubmed18950639 Reactome Database ID Release 431660517 Reactome, http://www.reactome.org ReactomeREACT_120918 Reviewed: Wakelam, Michael, 2012-05-14