PathwayStep1827 PathwayStep1828 PathwayStep1829 PathwayStep1830 PathwayStep1832 PathwayStep1831 PathwayStep1834 PathwayStep1833 PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane Synthesis of PIPs at the early endosome membrane At the early endosome membrane, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is generated in two steps from phosphatidylinositol 3,4-bisphosphate PI(3,4)P2 by the action of various kinases and phosphatases (Sbrissa et al. 2007, Sbrissa et al. 2008, Cao et al. 2007, Cao et al. 2008, Arcaro et al. 2000, Kim et al. 2002). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006661 Pubmed10805725 Pubmed11733541 Pubmed17556371 Pubmed17651088 Pubmed18524850 Pubmed18950639 Reactome Database ID Release 431660516 Reactome, http://www.reactome.org ReactomeREACT_120756 Reviewed: Wakelam, Michael, 2012-05-14