PathwayStep1811 PathwayStep1812 PathwayStep1810 PathwayStep1815 PathwayStep1816 PathwayStep1813 PathwayStep1814 PathwayStep1819 PathwayStep1817 PathwayStep1818 PathwayStep1820 PathwayStep1821 PathwayStep1822 PathwayStep1823 PathwayStep1806 PathwayStep1807 PathwayStep1808 PathwayStep1809 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane PI4P is dephosphorylated to PI by SYNJ at the plasma membrane PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane Synthesis of PIPs at the plasma membrane At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006661 Pubmed10224048 Pubmed11733541 Pubmed12536145 Pubmed12646134 Pubmed19896968 Pubmed9113989 Pubmed9211928 Pubmed9660759 Reactome Database ID Release 431660499 Reactome, http://www.reactome.org ReactomeREACT_121025 Reviewed: Wakelam, Michael, 2012-05-14