HNF6- and FGF10-dependent synthesis of PDX1 protein Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 Reactome Database ID Release 43210769 Reactome, http://www.reactome.org ReactomeREACT_13807 Reviewed: Jensen, J, 2008-05-12 21:46:53 The PDX1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription requires the activities of the HNF6 transcription factor and FGF10. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.