NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 Reactome Database ID Release 43211346 Reactome, http://www.reactome.org ReactomeREACT_13517 Reviewed: Jensen, J, 2008-05-12 21:46:53 The glucokinase (GCK) gene is transcribed and its mRNA is translated. GCK transcription is positively regulated by the activity of the NEUROD1 and PDX1 transcription factors. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.