PDX1-dependent synthesis of IAPP protein Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 Reactome Database ID Release 43211301 Reactome, http://www.reactome.org ReactomeREACT_13725 Reviewed: Jensen, J, 2008-05-12 21:46:53 The IAPP gene, encoding islet amyloid precursor protein, is transcribed and its mRNA is translated. IAPP transcription is positively regulated by PDX1 transcription factor. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.