RBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesis Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 Pubmed9111040 Reactome Database ID Release 43210834 Reactome, http://www.reactome.org ReactomeREACT_13473 Reviewed: Jensen, J, 2008-05-12 21:46:53 The HES1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus during morphogenesis of the pancreas. HES1 transcription requires the activity of the RBPJ transcription factor and the NOTCH1 intracellular domain, probably as a complex (Aster et al. 1997). These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.