phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex 43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit. Authored: Matthews, L, 2004-12-13 00:49:48 Edited: Matthews, L, 0000-00-00 00:00:00 Pubmed12588972 Pubmed14567916 Reactome Database ID Release 43156823 Reactome, http://www.reactome.org ReactomeREACT_1595