signal peptide polypeptide+signal:Translocon cleaved polypeptide:Translocon Signal peptide cleavage from ribosome-associated nascent protein As the signal peptide of the nascent protein enters the lumen of the endoplasmic reticulum (ER), the signal peptide is recognized and cleaved by the ER membrane-associated Signal Peptidase. Translation of the protein then proceeds to completion. Authored: May, B, Gopinathrao, G, 2008-11-19 19:22:37 EC Number: 3.4.21 Edited: May, B, Gopinathrao, G, 2008-11-19 19:22:37 Reactome Database ID Release 431799329 Reactome, http://www.reactome.org ReactomeREACT_115742 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31