80S:aminoacyl tRNA:mRNA:eEF1A:GTP 80S:Met-tRNAi:mRNA:aminoacyl-tRNA eEF1A:GDP Hydrolysis of eEF1A:GTP Authored: Gopinathrao, G, 2005-03-17 13:24:01 EC Number: 3.6.5.1 EC Number: 3.6.5.2 EC Number: 3.6.5.3 EC Number: 3.6.5.4 Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form of eEF1A is released from the ribosome.<br>This process is illustrated below with: an amino acyl-tRNA with an amino acid,a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA. Pubmed6568109 Reactome Database ID Release 43156923 Reactome, http://www.reactome.org ReactomeREACT_552