SRP receptor SRP receptor:SRP:ribosome:polypeptide+signal SRP:polypeptide+signal:ribosome The SRP receptor binds the SRP:nascent peptide:ribosome complex Authored: May, B, Gopinathrao, G, 2008-11-19 19:22:37 Edited: May, B, Gopinathrao, G, 2008-11-19 19:22:37 Pubmed12853463 Pubmed9631292 Reactome Database ID Release 431799330 Reactome, http://www.reactome.org ReactomeREACT_116124 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 The SRP receptor in the the endoplasmic reticulum (ER) membrane binds via its alpha subunit to the the SRP54 subunit of the Signal Recognition Particle (SRP), which itself is bound to a ribosome:mRNA:polypeptide complex. This interaction tethers the ribosome to the ER membrane, oriented so that the nacent polypeptide will traverse the ER membrane and enter the ER lumen. This process has been characterized in detail in cultured canine cells; this human event is inferred by homology from its canine counterpart.