DNA polymerase epsilon:origin complex primosome DNA polymerase alpha:primase:DNA polymerase alpha:origin complex DNA polymerase alpha:primase binds at the origin DNA polymerase alpha:primase is comprised of four subunits, p180, p70, p58, and p49. The two primase subunits, p58 and p49, form a tight complex. The p49 subunit contains the DNA primase activity and one role of p58 appears to be tethering p49 to p180, the DNA polymerase catalytic subunit. The fourth subunit, p70, binds p180 and may tether the DNA polymerase alpha:primase complex to Cdc45. Pubmed10757793 Pubmed10882098 Pubmed11395402 Pubmed12045100 Pubmed8253737 Reactome Database ID Release 4368914 Reactome, http://www.reactome.org ReactomeREACT_929