Unwound fork Replication Fork MCM8 mediated fork unwinding Authored: Tye, BK, 2005-11-29 10:17:56 Edited: Gopinathrao, G, 2005-11-29 21:05:54 Pubmed15707891 Reactome Database ID Release 43169461 Reactome, http://www.reactome.org ReactomeREACT_6768 The MCM2-7 related protein, MCM8, is required to replicate chromosomal DNA in Xenopus egg extracts. MCM8 binds chromatin upon initiation of DNA synthesis. It may function as an helicase in the elongation step.