Processive complex:Okazaki fragments:Remaining Flap RPA heterotrimer Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 Removal of RNA primer and dissociation of RPA and Dna2 Pubmed10748138 Pubmed11473323 Reactome Database ID Release 4369144 Reactome, http://www.reactome.org ReactomeREACT_315 The Dna2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and Dna2. The current data for the role of the Dna2 endonuclease has been derived from studies with yeast and Xenopus Dna2.