PathwayStep589 PathwayStep588 PathwayStep585 PathwayStep584 PathwayStep587 PathwayStep586 PathwayStep590 Dissociation of the TP:G13 complex Dissociation of the TP:Gq complex TP receptor can bind thromboxane Activated TP receptor binds G-proten Gq G13 activation by TP receptor Activated TP receptor binds G-protein G13 Gq activation by TP receptor Thromboxane signalling through TP receptor Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2009-11-03 Pubmed14751539 Pubmed18374420 Reactome Database ID Release 43428930 Reactome, http://www.reactome.org ReactomeREACT_20647 Reviewed: Harper, MT, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 Reviewed: Poole, AW, 2009-11-02 Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.