PathwayStep524 PathwayStep523 PathwayStep522 PathwayStep521 Activated prostacyclin receptor binds G-protein Gs Prostacyclin binds the Prostacyclin receptor PTGIR Gs activation by prostacyclin receptor Dissociation of the Prostacyclin receptor:Gs complex Prostacyclin signalling through prostacyclin receptor Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-06-07 Prostacyclin (PGI2) is continuously produced by healthy vascular endothelial cells. It inhibits platelet activation through interaction with the Gs-coupled receptor PTGIR, leading to increased cAMP, a consequent increase in cAMP-dependent protein kinase activity which prevents increases of cytoplasmic [Ca2+] necessary for activation (Woulfe et al. 2001). PGI2 is also an effective vasodilator. These effects oppose the effects of thromboxane (TXA2), another eicosanoid, creating a balance of blood circulation and platelet activation. Pubmed11413156 Pubmed17164137 Reactome Database ID Release 43392851 Reactome, http://www.reactome.org ReactomeREACT_23946 Reviewed: Kunapuli, SP, 2010-06-07