PathwayStep446 PathwayStep450 PathwayStep453 The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes Association of licensing factors with the pre-replicative complex Reactome Database ID Release 4369298 Reactome, http://www.reactome.org ReactomeREACT_1181 The eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex. CDC6 protein is synthesized under the control of E2F transcription factors