PathwayStep460 PathwayStep477 PathwayStep482 PathwayStep483 PathwayStep510 Cdt1 is displaced from the pre-replicative complex. Rearrangement and mobilization of Mcm2-7 Cdt1 associates with geminin Removal of licensing factors from origins Licensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of events in which the fates of different proteins at the origin are outlined. Reactome Database ID Release 4369300 Reactome, http://www.reactome.org ReactomeREACT_207 Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6