PathwayStep454 PathwayStep455 PathwayStep453 Free CDT1 associates with CDC6:ORC:origin complexes Ubiquitinated geminin is degraded by the proteasome The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 CDT1 association with the CDC6:ORC:origin complex Initiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. melanogaster, humans, and S. cerevisiae. Genetic studies in S. pombe have shown that binding of Cdc6 to chromatin requires the prior binding of Cdc18, the S. pombe homolog of Cdc6. In humans, the function of CDT1 is regulated during the cell cycle by its tight association with an inhibitory factor, geminin. Pubmed10766247 Pubmed10766248 Pubmed10898791 Pubmed11125146 Pubmed11175741 Pubmed11836525 Pubmed9442876 Pubmed9635433 Reactome Database ID Release 4368827 Reactome, http://www.reactome.org ReactomeREACT_1949