PathwayStep495 PathwayStep494 Processive synthesis on the leading strand Polymerase switching Leading Strand Synthesis Pubmed2175912 Pubmed7378348 Pubmed9191022 Reactome Database ID Release 4369109 Reactome, http://www.reactome.org ReactomeREACT_1838 The processive complex is responsible for synthesizing at least 5-10 kb of DNA in a continuous manner during leading strand synthesis. The incorporation of nucleotides by pol delta is quite accurate. However, incorporation of an incorrect nucleotide does occur occasionally. Misincorporated nucleotides are removed by the 3' to 5' exonucleolytic proofreading capability of pol delta.