PathwayStep486 PathwayStep485 PathwayStep488 PathwayStep487 MCM2-7 mediated fork unwinding Formation of GINS complex MCM8 mediated fork unwinding Multiple proteins are localized at replication fork Unwinding of DNA Authored: Tye, BK, 2006-03-17 14:46:24 DNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M phase of the cell cycle. DNA helicase activity of some of the MCM family proteins are important for the unwinding of DNA and initiation of replication processes. This section contains four events which have been proved in different eukaryotic experimental systems to involve various proteins for this essential step during DNA Replication. Edited: Gopinathrao, G, 2006-03-17 14:47:28 Pubmed10834843 Pubmed15707891 Reactome Database ID Release 43176974 Reactome, http://www.reactome.org ReactomeREACT_6776