PathwayStep476 PathwayStep475 PathwayStep474 PathwayStep473 Orc1 is phosphorylated by cyclin A/CDK2 Ubiquitinated Orc1 enters the cytosol Phosphorylated Orc1 is ubiquitinated while still associated with chromatin Ubiquitinated Orc1 is degraded by the proteasome Orc1 removal from chromatin Pubmed1110244 Pubmed11739726 Pubmed11809796 Pubmed11931757 Reactome Database ID Release 4368949 Reactome, http://www.reactome.org ReactomeREACT_1156