PathwayStep479 PathwayStep478 PathwayStep480 PathwayStep481 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex Phosphorylated Cdc6 is exported from the nucleus Ubiquitinated Cdc6 is degraded by the proteasome Cdc6 protein is phosphorylated by CDK CDK-mediated phosphorylation and removal of Cdc6 As cells enter S phase, HsCdc6p is phosphorylated by CDK promoting its export from the nucleus (see Bell and Dutta 2002). Pubmed11046155 Pubmed12045100 Reactome Database ID Release 4369017 Reactome, http://www.reactome.org ReactomeREACT_1221