capped oligoribonucleotide mature mRNA (eukaryotic, capped and deadenylated) 3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex Authored: May, B, 2009-07-22 Edited: May, B, 2009-07-22 Pubmed11283721 Pubmed14749774 Pubmed15231747 Pubmed15475613 Pubmed16141059 Pubmed17174896 Pubmed17245413 Pubmed17545563 Pubmed19060886 Pubmed19225159 Pubmed19239894 Reactome Database ID Release 43430028 Reactome, http://www.reactome.org ReactomeREACT_20588 Reviewed: Wilusz, J, 2009-09-17 The exosome complex hydrolyzes capped, deadenylated mRNA from 3' to 5' and yields ribonucleotides having 5'-monophosphates. In yeast the Ski2-Ski3-Ski8 complex assists degradation by the exosome complex, however little is known about the function of the homologous Ski complex in mammals. Although many exosomal components contain exonuclease signatures, only two components have been shown to degrade RNA. Rrp6/PMSCL-100 has been shown to be involved in the 3’-5’ decay of nuclear mRNAs in yeast. Rrp6 may also function in the absence of the core exosomal components. The Rrp44/dDis3 component of the core exosome has been shown to possess both 3’-5’ exonuclease activity along with endonuclease activity via its PIN domain.