Partially Deadenylated mRNA Complex mature mRNA (eukaryotic, capped and deadenylated) Deadenylation of mRNA by the CCR4-NOT Complex Authored: May, B, 2009-07-22 EC Number: 3.1.13.4 Edited: May, B, 2009-07-22 Pubmed10637334 Pubmed11283721 Pubmed11889047 Pubmed14749774 Pubmed15475613 Pubmed16141059 Pubmed16284618 Pubmed17245413 Pubmed18625844 Pubmed19239894 Pubmed19558367 Reactome Database ID Release 43429955 Reactome, http://www.reactome.org ReactomeREACT_20651 Reviewed: Wilusz, J, 2009-09-17 The CCR4-NOT complex hydrolyzes adenosine residues at the 3' end of polyadenylated mRNA, shortening the number of adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. CNOT6 and CNOT6L are the exoribonucleases responsible for hydrolysis. Activity of the CCR4-NOT complex is inhibited by PABP bound to the poly(A) tail of the mRNA. The trigger for activation of deadenylation by the CCR4-NOT complex is unknown. Complexes containing CNOT7 rather than CNOT8 appear to be responsible for cytoplasmic mRNA decay. eIF4A