Lsm1-7 Complex Deadenylated mRNA:Lsm1-7 Complex mature mRNA (eukaryotic, capped and deadenylated) Binding of Lsm1-7 Complex to Deadenylated mRNA Authored: May, B, 2009-07-22 Edited: May, B, 2009-07-22 Pubmed11283721 Pubmed14749774 Pubmed15231747 Pubmed15475613 Pubmed15711010 Pubmed16051491 Pubmed16141059 Pubmed17245413 Pubmed19239894 Pubmed19279404 Reactome Database ID Release 43429978 Reactome, http://www.reactome.org ReactomeREACT_20540 Reviewed: Wilusz, J, 2009-09-17 The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.