PathwayStep993 PathwayStep950 PathwayStep971 PathwayStep978 Glucose metabolism Authored: Schmidt, EE, 2003-02-05 00:00:00 Edited: D'Eustachio, P, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0006006 Glucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood cells. Glucose utilization begins with its uptake by cells and conversion to glucose 6-phosphate, which cannot traverse the cell membrane. Fates open to cytosolic glucose 6-phosphate include glycolysis to yield pyruvate, glycogen synthesis, and the pentose phosphate pathway. In some tissues, notably the liver and kidney, glucose 6-phosphate can be synthesized from pyruvate by the pathway of gluconeogenesis. Reactome Database ID Release 4370326 Reactome, http://www.reactome.org ReactomeREACT_723 Gluconeogenesis Glycolysis Glycogen breakdown (glycogenolysis) Glycogen synthesis