PathwayStep1191 PathwayStep1111 PathwayStep2020 PathwayStep2104 PathwayStep2801 PathwayStep2628 PathwayStep2606 PathwayStep2764 PathwayStep2779 PathwayStep2792 PathwayStep2757 PathwayStep2403 PathwayStep2145 PathwayStep2199 PathwayStep2328 Metabolism of lipids and lipoproteins Inositol phosphate metabolism Amino acid and derivative metabolism Metabolism of vitamins and cofactors Nucleotide metabolism Metabolism of nitric oxide The citric acid (TCA) cycle and respiratory electron transport Integration of energy metabolism Metabolism GENE ONTOLOGYGO:0044281 Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether they involve carbohydrate-derived or lipid-derived molecules, and within each group it is useful to distinguish processes that mediate the breakdown and oxidation of these molecules to yield energy from ones that mediate their synthesis and storage as internal energy reserves. Synthetic reactions are conveniently grouped by the chemical nature of the end products, such as nucleotides, amino acids and related molecules, and porphyrins. Detoxification reactions (biological oxidations) are likewise conveniently classified by the chemical nature of the toxin.<p>At the same time, all of these processes are tightly integrated. Intermediates in reactions of energy generation are starting materials for biosyntheses of amino acids and other compounds, broad-specificity oxidoreductase enzymes can be involved in both detoxification reactions and biosyntheses, and hormone-mediated signaling processes function to coordinate the operation of energy-generating and energy-storing reactions and to couple these to other biosynthetic processes. Reactome Database ID Release 431430728 Reactome, http://www.reactome.org ReactomeREACT_111217 Carbohydrate metabolism Biological oxidations Porphyrin metabolism O2/CO2 exchange in erythrocytes Mitochondrial Iron-Sulfur Cluster Biogenesis Reversible Hydration of Carbon Dioxide Abacavir transport and metabolism