pre-microRNA with 3' overhang pri-microRNA Microprocessor complex cleaves pri-miRNA to pre-miRNA Authored: Gopinathrao, G, May, B, 2007-11-18 23:55:40 EC Number: 3.1.26.3 Edited: May, B, 2009-06-16 Nuclear processing by Drosha Microprocessor complex. The primary-microRNA (pri-miRNA) is recognized by the Microprocessor complex (Drosha:DGCR8) and both strands of the pri-miRNA are cleaved by Drosha near the free 5' and 3' ends of the pri-miRNA, that is, at the ends distal from the internal loop. The product is a double-stranded RNA having 2 nucleotides protruding at the 3' end and having an internal loop. Pubmed14508493 Pubmed15531877 Pubmed15531879 Pubmed15574589 Reactome Database ID Release 43203893 Reactome, http://www.reactome.org ReactomeREACT_12414 Reviewed: Karginov, F, Hannon, GJ, 2008-02-08 15:41:16