PathwayStep860 PathwayStep855 PathwayStep854 PathwayStep853 PathwayStep859 PathwayStep858 PathwayStep857 PathwayStep856 Organic anion transporters Authored: Jassal, B, 2009-07-06 Edited: Jassal, B, 2009-07-06 Pubmed12811560 Pubmed18446519 Reactome Database ID Release 43428643 Reactome, http://www.reactome.org ReactomeREACT_19372 Reviewed: He, L, 2009-08-24 The SLC17 gene family encode proteins which are organic anion transporters. There are three distinct subfamilies within SLC17; vesicular glutamate transporters (VGLUT1-3 encoded by SLC17A7,6 and 8), type I Na+-coupled phosphate co-transporters (encoded by SLC17A1-4) and a proton-coupled sialic acid co-transporter (encoded by SLC17A5) (Reimer RJ and Edwards RH, 2004).<br><br>Two members of the SLC5 gene family encode carboxylate transporters, SMCT1 and SMCT2 (Ganapathy V et al, 2008). malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] Passive I- efflux mediated by SMCT1 Sulfate is exported to the cytosol in exchange for dicarboxylate Na+-dependent monocarboxylate transport by SMCT Vesicular glutamate transport Type I Na+-coupled phosphate co-transport Proton-coupled sialic acid co-transport Na+/I- cotransport (influx) by the Na+/I- symporter