PathwayStep907 Proton-coupled monocarboxylate transport Authored: Jassal, B, 2009-08-25 Edited: Jassal, B, 2009-08-25 Pubmed18523892 Pubmed19085840 Reactome Database ID Release 43433692 Reactome, http://www.reactome.org ReactomeREACT_20515 Reviewed: He, L, 2009-11-12 The SLC16A gene family encode proton-linked monocarboxylate transporters (MCT) which mediate the transport of monocarboxylates such as lactate and pyruvate. Monocarboxylates are a major energy source for all cells in the body so their transport in and out of cells is crucial for cellular function. To date, 14 SLC16A members have been identified through sequence homology. Of these 14 members, only seven isoforms have been functionally characterized and not all of these function as proton-coupled transporters. A number can transport diuretics, thyroid hormones and aromatic amino acids. The seven remaining SLC16A members are classed as orphan MCTs (Morris ME and Felmlee MA, 2008; Merezhinskaya N and Fishbein WN, 2009). MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies